Scientist / Senior Scientist - TCR engineering and TCE development (San Francisco) Job at Shennon Biotechnologies, San Francisco, CA

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  • Shennon Biotechnologies
  • San Francisco, CA

Job Description

Overview

We are a well-funded biotech startup that has developed a suite of proprietary technologies combining ultrahigh throughput single cell functional screening with computational AI models to advance immunotherapies for cancer and autoimmune diseases. We are looking for a protein engineering scientist with experience in TCR affinity maturation and T cell engager (TCE) development to join our interdisciplinary team. The candidate should adapt quickly and communicate well in a fast-paced startup environment and collaborate with other team members.

Responsibilities

  • Design libraries and perform TCR affinity maturation using yeast or phage display.
  • Lead TCR engineering efforts for enhanced affinity, specificity, and stability.
  • Partner with AI/ML scientists to design sequences and libraries, contributing to iterative design-build-test cycles to advance therapeutic candidates.
  • Collaborate with the team to develop TCEs and conduct in vitro functional assays to assess efficacy and safety.
  • Work with CRO on TCR/TCE production and binding characterization.

Skills and Qualifications

  • PhD in Biochemistry, Molecular Biology, Bioengineering, Immunology, or a related field.
  • Expertise in display technologies (yeast or phage), and high-throughput TCR/antibody screening.
  • Experience in TCR, antibody or protein engineering, including affinity maturation, deep mutational scanning, cross-reactivity, and biophysical property optimization.
  • Experience with TCR/antibody library construction, screening, and binding measurement.
  • Fundamental understanding of TCR/antibody and structure-function relationships.
  • Familiarity with protein structure analysis tools (PyMOL, Chimera, MOE).
  • Ability to work in a fast-paced startup environment, take initiative, and drive projects forward independently.
  • Excellent communication and collaboration skills.

Preferred Qualifications

  • Experience with bispecific antibodies and format screening.
  • Background in T Cell Engager development.
  • Experience with mammalian expression systems and protein purification techniques.

Compensation and Benefits

  • $120,000 - $160,000 (depending on depth of expertise) + 10% performance bonus + equity.
  • 4% 401K match; Daily lunches; Commuter benefits; Unlimited snacks and drinks.
  • Disability Insurance, Life Insurance; Workplace Insurance.
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